As a gesture of appreciation for being long term customers I won't charge extra
for crop I sprayed with roundup.
Some of you haters might have trouble with this one because it is actually
science and therefore has some big words.
http://www.ncbi.nlm.nih.gov/pubmed/23983455
Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular
glycine synthesis.
Li Q1, Lambrechts MJ, Zhang Q, Liu S, Ge D, Yin R, Xi M, You Z.
Author information
Abstract
Glycine is a nonessential amino acid that is reversibly converted from serine
intracellularly by serine hydroxymethyltransferase. Glyphosate and its
degradation product, aminomethylphosphonic acid (AMPA), are analogs to glycine,
thus they may inhibit serine hydroxymethyltransferase to decrease intracellular
glycine synthesis. In this study, we found that glyphosate and AMPA inhibited
cell growth in eight human cancer cell lines but not in two immortalized human
normal prostatic epithelial cell lines. AMPA arrested C4-2B and PC-3 cancer
cells in the G1/G0 phase and inhibited entry into the S phase of the cell cycle.
AMPA also promoted apoptosis in C4-2B and PC-3 cancer cell lines. AMPA
upregulated p53 and p21 protein levels as well as procaspase 9 protein levels in
C4-2B cells, whereas it downregulated cyclin D3 protein levels. AMPA also
activated caspase 3 and induced cleavage of poly (adenosine diphosphate [ADP]-
ribose) polymerase. This study provides the first evidence that glyphosate and
AMPA can inhibit proliferation and promote apoptosis of cancer cells but not
normal cells, suggesting that they have potentials to be developed into a new
anticancer therapy.
for crop I sprayed with roundup.
Some of you haters might have trouble with this one because it is actually
science and therefore has some big words.
http://www.ncbi.nlm.nih.gov/pubmed/23983455
Glyphosate and AMPA inhibit cancer cell growth through inhibiting intracellular
glycine synthesis.
Li Q1, Lambrechts MJ, Zhang Q, Liu S, Ge D, Yin R, Xi M, You Z.
Author information
Abstract
Glycine is a nonessential amino acid that is reversibly converted from serine
intracellularly by serine hydroxymethyltransferase. Glyphosate and its
degradation product, aminomethylphosphonic acid (AMPA), are analogs to glycine,
thus they may inhibit serine hydroxymethyltransferase to decrease intracellular
glycine synthesis. In this study, we found that glyphosate and AMPA inhibited
cell growth in eight human cancer cell lines but not in two immortalized human
normal prostatic epithelial cell lines. AMPA arrested C4-2B and PC-3 cancer
cells in the G1/G0 phase and inhibited entry into the S phase of the cell cycle.
AMPA also promoted apoptosis in C4-2B and PC-3 cancer cell lines. AMPA
upregulated p53 and p21 protein levels as well as procaspase 9 protein levels in
C4-2B cells, whereas it downregulated cyclin D3 protein levels. AMPA also
activated caspase 3 and induced cleavage of poly (adenosine diphosphate [ADP]-
ribose) polymerase. This study provides the first evidence that glyphosate and
AMPA can inhibit proliferation and promote apoptosis of cancer cells but not
normal cells, suggesting that they have potentials to be developed into a new
anticancer therapy.